GHK-Cu

Each lot of GHK-Cu supplied for research is characterized by analytical methods to confirm identity and purity:

• Purity: reversed-phase HPLC, verified to ≥99%.
• Identity: mass spectrometry (MS) to confirm the molecular mass of the glycyl-L-histidyl-L-lysine–copper(II) complex.
• Reference identifiers: the free tripeptide GHK is associated with CAS 49557-75-7 (molecular formula C₁₄H₂₄N₆O₄), and the copper(II) complex GHK-Cu with CAS 89030-95-5 (molecular formula C₁₄H₂₂CuN₆O₄). Exact lot-specific values are reported on the COA.
• Certificate of Analysis: a lot-specific COA accompanies each lot, reporting measured purity, identity, and appearance.

These analytical characterizations describe identity and purity of the supplied material only. They do not represent any evaluation of biological activity, efficacy, or safety. For research use only, not for human use.

A Certificate of Analysis is available per production lot, documenting HPLC purity and mass-spectrometry identity confirmation.

View Certificates of Analysis →

For Research Use Only · Not for human or veterinary use · Not for diagnostic or therapeutic use.

References to clinical phases/studies describe the compound in independent third-party literature (e.g., ClinicalTrials.gov, PubMed) and do not represent claims, testing, or approval by Zynix Biolab.

GHK-Cu is the copper(II) complex of the tripeptide glycyl-L-histidyl-L-lysine (GHK). GHK is a naturally occurring sequence first isolated from human plasma, and it has been studied in the literature as a copper-binding ligand that forms a coordination complex with copper(II) ions. In this complex, the copper ion is the characteristic feature giving the lyophilized material its blue color.

In the published, third-party scientific literature, GHK-Cu has been the subject of investigation as a model copper-peptide system. Reported research has examined its proposed role in modulating extracellular-matrix-related signaling, gene expression, and copper homeostasis in in vitro and laboratory models. Reviews of the compound have characterized it as a modulator of multiple cellular pathways associated with tissue repair and as a system for studying copper transport and antioxidant chemistry (see, for example, Pickart & Margolina, Int. J. Mol. Sci. 2018).

GHK-Cu is studied predominantly in cosmetic-science and cell-biology research contexts rather than as an investigational human drug. No interventional human clinical-trial program defining a formal “study phase” for this compound is asserted here. Where it appears in the literature, it does so as a research and cosmetic-ingredient compound that has been characterized and examined in published peer-reviewed work.

For Research Use Only · Not for human or veterinary use · Not for diagnostic or therapeutic use.

In the published literature, GHK-Cu has been examined in laboratory and in vitro research lines, including:

• Coordination chemistry of copper(II)–peptide complexes and copper-binding behavior.
• In vitro studies of extracellular-matrix-associated signaling, including collagen and glycosaminoglycan synthesis in cultured fibroblast models.
• Gene-expression and transcriptomic profiling in cell-culture systems.
• Cosmetic-science and topical-formulation research evaluating the compound as a characterized ingredient.
• Antioxidant and copper-homeostasis chemistry in model systems.

These research applications are provided for scientific context only and describe published work by third parties using the compound in laboratory settings. This product is not for human use, diagnostic use, or therapeutic use.

General laboratory handling guidance for research personnel:

• Storage: store the lyophilized powder at -20°C, protected from light and moisture. Allow sealed vials to reach room temperature before opening to limit condensation.
• Reconstitution: for laboratory preparation, the lyophilized material may be reconstituted with bacteriostatic water or another suitable research-grade solvent, swirling gently rather than shaking. Reconstituted solutions are typically stored refrigerated and used within a short working window per the lab’s protocol.
• PPE: handle with appropriate personal protective equipment (gloves, eye protection, lab coat) and standard laboratory technique under a qualified researcher.

This information describes general laboratory handling and is not a dosing or administration instruction. For research use only — not for human use.

For Research Use Only · Not for human or veterinary use · Not for diagnostic or therapeutic use.

• Pickart L, Vasquez-Soltero JM, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. BioMed Research International. 2015;2015:648108. DOI: 10.1155/2015/648108.
• Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. International Journal of Molecular Sciences. 2018;19(7):1987. PMID: 29986520; DOI: 10.3390/ijms19071987.
• Pickart L, Vasquez-Soltero JM, Margolina A. The Human Tripeptide GHK-Cu in Prevention of Oxidative Stress and Degenerative Conditions of Aging: Implications for Cognitive Health. Oxidative Medicine and Cellular Longevity. 2012;2012:324832. PMID: 22666519; DOI: 10.1155/2012/324832.

These references are provided for scientific context only and are not claims by Zynix Biolab.